The British journal of dermatology
The role of PKC subtype-specific signaling in the regulation of adhesion in human keratinocytes and skin in pemphigus.
Thomas Schmitt, Julia Haneberg, Desalegn Egu, Carla Sebastià Morón, Enno Schmidt, Christoph Hudemann, Michael Hertl, Takashi Hashimoto, Jens Waschke
Published: 202510.1093/bjd/ljaf458
Abstract
AIM: Autoantibodies, in the blistering skin disease pemphigus primarily target desmosomal cadherins and cause loss of keratinocyte adhesion and epidermal blistering via signaling events. Pemphigus vulgaris is associated with autoantibodies (PV-IgG) a…
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