The British journal of dermatology
Excessive Glycine Loop Variations in the Keratin 10 Tail Domain and Implications for Skin Fragility.
Zihao Mi, Yueqian Yu, Zhenzhen Wang, Fuxiang Bai, Gongqi Yu, Bingqing Li, Yuanji Dai, Yingjie Lin, Xu Sang, Jinghong Han, Xiaojiao Tu, Yi Wang, Nan Cao, Hong Liu, Furen Zhang
Published: 202510.1093/bjd/ljaf436
Abstract
BACKGROUND: Keratins are vital structural proteins forming intermediate filaments (IFs). They lead to various inherited skin fragilities when dysfunctional. The keratin tail domain is essential for the proper functioning of IF, with glycine loop vari…
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