Biology of reproduction
Gestational Intermittent Hypoxia Programs Pregnancy-Specific Salt-Sensitive Postpartum Hypertension and Vascular Dysfunction via Disruption of NO/cGMP/PKG Pathway†.
Ruolin Song, Pankaj Yadav, Alissa Hofmann, Jay Mishra, Sathish Kumar
Published: 202510.1093/biolre/ioaf289
Abstract
Obstructive sleep apnea (OSA), common in pregnancy, is linked to preeclampsia and long-term maternal hypertension, but the underlying mechanisms remain unclear. We hypothesized that intermittent hypoxia (IH), a core feature of OSA, primes the materna…
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