American journal of hypertension
SIRT3 Activation by SGLT2 Inhibitor Mitigates Endothelial-to-Mesenchymal Transition in Dahl Salt-Sensitive Rats Induced by High-Salt Diet.
Xiu-Heng Wang, Jia-Yang Yang, Zheng-Wen Lei, Xue-Ting Zheng, Hui-Yi Xie, Hong Huang, Hui-Fang Tang, Yue Zhao, Zhi-Sheng Jiang, Heng-Jing Hu
Published: 202510.1093/ajh/hpaf209
Abstract
BACKGROUND: Salt-sensitive hypertension (SSHT) is associated with reduced expression of SIRT3 and promotes endothelial-mesenchymal transition (EndMT). Sodium-glucose cotransporter 2 (SGLT2) inhibitors, such as dapagliflozin (DAPA), have been shown to…
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