American journal of epidemiology
Statistical approaches for systematically missing covariates in individual participant data meta-analysis: insights and applications using 5 large cardiovascular trials.
Robert Thiesmeier, Paul M Haller, Siddharth M Patel, Erin A Bohula, David A Morrow, Sabina A Murphy, Michelle L O'Donoghue, Marc S Sabatine, Benjamin S Scirica, Deepak L Bhatt, Nicola Orsini, Andrea Bellavia
Published: 202510.1093/aje/kwaf226
Abstract
Combining multiple studies for evidence synthesis can improve the precision of effect estimates and enable investigation of more granular clinical research questions. However, individual participant data (IPD) meta-analyses are often limited by the p…
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