Molecular biology of the cell
Wnt signaling is modulated by the buffer-like properties of cadherins.
Lauren Schnitkey, Christin Anthony, Marina Cardó-Vila, Matthew A Loberg, Gemma Orton, Allison McCabe, Jonathan Trapani, Mary Rockouski, Joyce Luo, Sheau-Chiann Chen, Fei Ye, David J Robbins, Yashi Ahmed, Konstantin Doubrovinski, Vivian L Weiss
Published: 202610.1091/mbc.E25-04-0191
Abstract
β-catenin is a critical effector of the Wnt pathway and a key component of the cadherin complex. Whether Wnt-regulated cytoplasmic β-catenin interacts with the cadherin-associated pool under physiological conditions is unclear. Using a cell line depl…
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