The Journal of experimental medicineJanus Kinase 2ThrombocytosisSTAT1 Transcription FactorHumansAnimals
JAK2/JAK2V617F heterodimers activate STAT1 and AhR to promote thrombocytosis.
Radek C Skoda, Olli Silvennoinen
Published: 202510.1084/jem.20251880
Abstract
In this issue of JEM, Zhou et al. (https://doi.org/10.1084/jem.20250153) report that hematopoietic progenitors heterozygous for the JAK2V617F mutation preferentially activate STAT1, promoting platelet production and thrombocythemia, whereas homozygou…
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