The Journal of experimental medicineHumansInterferon Regulatory FactorsAnimalsGenetic DiseasesInborn
Monogenic disorders of the IRF transcription factors.
Mattison P Stojcic, Pariya Yousefi, Catherine M Biggs, Stuart E Turvey
Published: 202610.1084/jem.20250939
Abstract
Interferon regulatory factors (IRFs) are a family of transcription factors essential for immune system development and host defense. Beyond immunity, IRF6 plays an indispensable role in craniofacial development. Inborn errors of IRFs (IE-IRFs) are a…
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