The Journal of cell biologyCD47 AntigenProto-Oncogene Proteins c-vavPhagocytosisAnimalsPhosphorylation
CD47 inhibits phagocytosis through Vav dephosphorylation.
Wyatt D Miller, Andrew Manion, Abhinava K Mishra, Connor J Sheedy, Annalise Bond, Brooke M Gardner, Denise J Montell, Meghan A Morrissey
Published: 202510.1083/jcb.202502206
Abstract
CD47 on viable cells protects against phagocytosis. CD47 is recognized by SIRPα, an inhibitory receptor expressed by macrophages and other myeloid cells. Activated SIRPα recruits SHP-1 and SHP-2 phosphatases, but the inhibitory signaling cascade down…
Preview only. Read the full abstract at the source