The Journal of cell biologyEndoplasmic ReticulumPhospholipid Transfer ProteinsSaccharomyces cerevisiae ProteinsSaccharomyces cerevisiaeHomeostasis
Ist2 is a phospholipid scramblase that links lipid transport at the ER to organelle homeostasis.
Heitor Gobbi Sebinelli, Camille Syska, Hafez Razmazma, Véronique Albanèse, Ana Rita Dias Araujo, Cecile Hilpert, Cédric Montigny, Christine Jaxel, Manuella Tchamba, Karolina Belingar, Juan Martín D'Ambrosio, Luca Monticelli, Guillaume Lenoir, Alenka Čopič
Published: 202610.1083/jcb.202502112
Abstract
Lipid scramblases allow passive flip-flop of phospholipids between bilayer leaflets, thereby promoting membrane symmetry. At the endoplasmic reticulum (ER), where phospholipid synthesis is restricted to one leaflet, scramblase activity should be esse…
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