The Journal of cell biologyChemokine CCL21Dendritic CellsUrokinase-Type Plasminogen ActivatorAnimalsCell Movement
uPA-mediated remodeling of CCL21 gradients regulates lymphatic migration of dendritic cells.
Victor Collado-Diaz, Maria-Nefeli Christakopoulou, Philipp Schineis, Katharina Blatter, David Laubender, Sébastien Trzebanski, Marina Thoma, Yves Gadient, Hazal Tatliadim, Konstantinos Gkelis, Mona C Friess, Vladimir Purvanov, Guerric P B Samson, Marc Artinger, Radjesh Bisoendial
Published: 202610.1083/jcb.202412190
Abstract
Dendritic cell (DC) migration via afferent lymphatics to draining LNs (dLNs) occurs in distinct steps that require the chemokine C-C motif ligand 21 (CCL21). In addition to full-length CCL21, which forms an immobilized perilymphatic gradient, a trunc…
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