The Journal of cell biologyPhosphorylationCell MembraneHumansMembrane ProteinsMitosis
Adapting plasma membrane for mitotic cell rounding through Aurora A phosphorylation of numb.
Yanyan Li, Ke Liu, Xian Lin, Zhihao Ding, Haiyan Sun, Xiangyun Liao, Binghua Cheng, Wenli Shi, Junde Xu, Jiaming Liang, Zeyu Zhou, Wenjie Zhou, Hui Tian, Long Meng, Guangyong Chen
Published: 202510.1083/jcb.202412005
Abstract
Cell rounding during mitosis necessitates adaptive remodeling of plasma membrane and cortical cytoskeleton. However, the underlying mechanisms remain poorly elucidated. Here, we have identified Numb phosphorylation as a pivotal mechanism in the membr…
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