Utilizing community engagement to define research and clinical priorities for gender-affirming hormone therapy.

Background: Transgender and gender diverse (TGD) populations are often excluded from research or inappropriately grouped with other gender modalities despite significant disparities in health and health care. According to models of community-engaged research, involving TGD community members in establishing research priorities can improve the relevance and impact of research for this population. The purpose of this study was to clarify community priorities for research relevant to TGD populations. Methods: Forty-five individuals participated across five asynchronous online focus groups. Participants discussed topics chosen in collaboration with a community research advisory board, including gender-affirming hormone therapy. Rapid qualitative analysis was used to identify salient themes. Results: Research priorities voiced across all represented gender identities were: (1) Longitudinal, prospective research on long-term effects of gender-affirming hormone therapy, (2) Standardized training for providers and researchers, (3) Implementation research on methods to educate the public and reduce discrimination, and (4) Basic research on the biological, historical, and social underpinnings of gender identity. Conclusions: This study provides insight into clinical priorities for TGD populations. Findings highlight a need for basic science research to better understand the underpinnings of gender identity, longitudinal studies to investigate long-term effects of hormone therapy, and education for the public on gender diversity to combat discrimination.