Emerging microbes & infectionsHumansHIV InfectionsHigh-Throughput Nucleotide SequencingHIV Integrase InhibitorsDrug Resistance
Deep sequencing reveals underestimated burden of integrase inhibitor resistance mutations in people living with HIV: a global individual patient data meta-analysis.
Defu Yuan, Fei Zhao, Yangyang Liu, Shanshan Liu, Hongxia Yan, Lifeng Liu, Tong Zhang, Bei Wang, Bin Su
Published: 202510.1080/22221751.2025.2595793
Abstract
Integrase strand transfer inhibitors (INSTIs) have emerged as cornerstone agents in global antiretroviral therapy, though growing drug resistance presents clinical challenges. Conventional Sanger sequencing may underestimate the burden of low-frequen…
Preview only. Read the full abstract at the source