Perceived risk and time costs as correlates of hepatitis vaccine hesitancy among Chinese university students: A ten‑university cross‑sectional study.
Zhenwei Li, Binyue Xu, Haiyan Yang, Hongling Wen, Qi Wang, Xiaomei Dong, Hong Gao, Caijun Sun, Minghuan Jiang, Hong Li, Peihang Chen, Yingqi Chen, Hongni Wang, Chuanxi Fu
Abstract
Open AccessTo estimate the prevalence of hepatitis vaccine hesitancy among Chinese university students and identify modifiable correlates to guide campus programs. We ran a multicampus cross-sectional survey (December 2023-February 2024) using a two-stage stratified cluster design across eastern, central, and western China. Hesitancy was measured with an 11 item hepatitis-adapted Vaccine Hesitancy Scale (α = 0.83). Multivariable logistic regression examined Health Belief Model constructs and convenience (travel/visit time). Among 2526 respondents, 51.8% met the prespecified hesitancy threshold. Seniors were more hesitant than juniors (aOR = 1.55, 95% CI: 1.25-1.91); students in the central region exceeded those in the east (1.30, 1.07-1.59). Off-campus residence (0.58, 0.41-0.83) and non-medical majors (0.68, 0.54-0.85) had lower odds. Higher perceived risk was also associated with lower hesitancy (0.66, 0.55-0.78). Ordering takeout showed a dose - response (e.g. 3-4/week vs never: 2.52, 1.67-3.82), whereas sharing tableware/drinkware was inversely associated (e.g., 3-4/week vs never: 0.38, 0.23-0.63). Time costs mattered: travel time >30 minutes was linked to higher hesitancy (1.43, 1.06-1.94), and unclear visit duration was also associated (1.40, 1.02-1.93). Hepatitis vaccine hesitancy is common among university students. Two modifiable levers - risk perception and service convenience - support highyield campus strategies.