Rehabilitation intervention to prevent adverse events related to ADT in patients with metastatic prostate cancer.

In patients with prostate cancer (PCa), androgen deprivation therapy (ADT) is associated with multiple side effects, including increased fat mass (FM), loss of muscle mass and strength, osteoporosis, risk of falls, disability, fatigue, and a decline in quality of life (QoL). Multicomponent exercise programs have been shown to mitigate several of these adverse events. Preliminary evidence suggests that exercise can be safely implemented in patients with metastatic PCa and that physical inactivity should be avoided, even in advanced stages. However, studies involving this fragile population remain limited. This single-arm interventional study aims to evaluate the feasibility and safety of an exercise-based rehabilitation program in hormone-sensitive patients undergoing ADT, alone or combined with other therapies.