Accurate quantification of anti-drug antibodies against each unique Fab of a bispecific antibody using an ECL bridging assay.

AIM: To develop an anti-drug antibody (ADA) assay for a bispecific antibody (bsAb) we will refer to as Drug-1, and to quantify the ADAs against each specific fragment antigen-binding (Fab) site of Drug-1. MATERIALS AND METHODS: Here we use two additi…

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