Bioanalysis
Mitigating ADA matrix interferences: semiquantitative double immunoprecipitation for anti-bevacizumab antibody in plasma.
Yu Gus Hui, Fang Wang, Jian Wu, Emmalyn Dupree, M Shane Woolf, Kumar Shah, Moucun Yuan, William R Mylott
Published: 202610.1080/17576180.2025.2608563
Abstract
BACKGROUND: Hybrid LC - MS/MS methodology offers orthogonal ADA quantitation but is limited by endogenous immunoglobulin matrix interference challenges. METHODS: We developed a novel semi-quantitative LC-MS/MS isotyping assay for rabbit IgG/IgM immun…
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