Bioanalysis
Streamlined neutralizing antibody assay development: overcoming serum interference, utilization of DOE and automation.
Kelly Ngoc Pham, Nazneen Bano, Leonard J Rubinstein, James Schiller, Wolfgang Seghezzi, Faye Vazvaei-Smith, Weifeng Xu
Published: 202610.1080/17576180.2025.2608560
Abstract
OBJECTIVE: This study detailed the troubleshooting and optimization of a challenging neutralizing antibody (NAb) assay using a previously published PEG precipitation, Acid Dissociation, and Biotin-drug as Assay Drug (PABAD) method to overcome high dr…
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