Future medicinal chemistryThymidine Phosphorylasealpha-GlucosidasesKineticsMolecular Docking SimulationHumans
Synthesis, in vitro and kinetic study of thiazolidinone derivatives: insight from a network medicinal approach for thymidine phosphorylase and alpha glucosidase.
Shoaib Khan, Tayyiaba Iqbal, Sampath Chinnam, Eman Alzahrani, Sobhi M Gomha, Magdi E A Zaki, Faez Falah Alshehri, Zafer Saad Al Shehri, Hamdy Kashtoh
Published: 202510.1080/17568919.2025.2571026
Abstract
AIMS: This study aimed to design, synthesize, and evaluate a novel series of pyridine-linked thiazolidinone analogues (1-15) as dual inhibitors of thymidine phosphorylase and α-glucosidase, with potential therapeutic applications in diabetes mellitus…
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