Expert opinion on drug metabolism & toxicologyHumansChemical and Drug Induced Liver InjuryUnited States Food and Drug AdministrationUnited StatesBiomarkers
Modifying Hy's Law and eDISH for the modern idiosyncratic DILI era.
Eric B Cohen, James H Lewis
Published: 202510.1080/17425255.2025.2577677
Abstract
INTRODUCTION: Dr. Hyman Zimmerman observed that 'hepatocellular jaundice' was a prognostic biomarker of severe drug-induced liver injury (DILI). His sentinel observation eventually became known as 'Hy's Law' which the FDA currently defines as an ALT…
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