Personalized medicineHumansTacrolimusKidney TransplantationTunisiaMale
A population pharmacokinetic model for early follow-up dosing of tacrolimus in Tunisian kidney transplant recipients.
Amani Abderahmene, Marith I Francke, Meriam Ammar, Louise M Andrews, Dennis A Hesselink, Dorra Amor, Wissal Sahtout, Azzabi Awatif, Ali Bouslama, Dorsaf Zellama, Asma Omezzine, Brenda C M De Winter
Published: 202510.1080/17410541.2025.2606641
Abstract
INTRODUCTION: Tacrolimus is the cornerstone of immunosuppressive therapy in kidney transplantation. However, it exhibits significant pharmacokinetic (PK) variability among patients. Therefore, Population Pharmacokinetic (PopPK) modeling is crucial fo…
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