Autophagy
Senecavirus a VP2 protein orchestrates PRDX1 degradation through dual autophagy pathways: macroautophagy and chaperone-mediated autophagy.
Zhaoyang Li, Xiaoyu Yang, Jingyu Mao, Penghui Zeng, Yuxiang Qi, Yongyan Shi, Jinshuo Guo, Jianwei Zhou, Dedong Wang, Jue Liu, Lei Hou
Published: 202610.1080/15548627.2025.2610449
Abstract
Co-adaptation between viruses and autophagy has equipped viruses with diverse strategies to regulate host redox homeostasis, thereby facilitating viral replication. However, the mechanisms by which viruses manipulate PRDX1 (peroxiredoxin 1), a key an…
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