Autophagy
A self-sensing vacuole/lysosome: V-ATPase dysfunction activates selective autophagy.
Yuxiang Huang, Daniel J Klionsky
Published: 202610.1080/15548627.2025.2604345
Abstract
Macroautophagy/autophagy has long been viewed as being strictly dependent on vacuolar or lysosomal acidity, with the vacuolar-type H+-translocating ATPase (V-ATPase) functioning mainly as a proton pump that sustains degradation. Our recent paper over…
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