Cancer biology & therapyHumansAnimalsAmino Acid Transport System ASCMiceEsophageal Neoplasms
Glutamine transporter SLC1A5 inhibits autophagy-mediated CD276 degradation to promote esophageal cancer progression.
Chunyan Wang, Hongyan Zhang, Chaonan Guan, Yuying Li, Shengli Yang, Lan Huang
Published: 202610.1080/15384047.2026.2621606
Abstract
BACKGROUND: CD276/B7-H3 is an immune checkpoint molecule often overexpressed in cancers, representing a potential therapeutic target. The underlying mechanisms for CD276 upregulation remain unclear. This study investigates how glutamine metabolism af…
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