Nucleosides, nucleotides & nucleic acids
Nucleoterpenoids on the basis of diterpenoid isosteviol, nucleobases and nucleoside analogues. Synthesis and cytotoxicity of a series of conjugates of isosteviol and uracil. Part 2.
Olga V Andreeva, Bulat F Garifullin, Alexandra D Voloshina, Anna P Lyubina, Andrey A Parfenov, Irina Yu Strobykina, Mayya G Belenok, Ravil F Aznagulov, Liliya F Saifina, Olga B Babaeva, Vyacheslav E Semenov, Vladimir E Kataev
Published: 202510.1080/15257770.2025.2570265
Abstract
A series of conjugates of diterpenoid isosteviol (16-oxo-ent-beyran-19-oic acid) and uracil (nucleoterpenoids) was synthesized and examined for their in vitro cytotoxicity against 9 human cancer cell lines. Nucleoterpenoids 13c,f,15 exhibited the bes…
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