Journal of chemotherapy (Florence, Italy)
USP54 suppresses bladder cancer proliferation, stemness, and cisplatin resistance via deubiquitination-mediated stabilization of SIRT6.
Yinan Han, Shengxing Wang, Rurui Xia, Bangfen Zhou, Shigong Huang, Wengui Xie, Shijie Guo
Published: 202510.1080/1120009X.2025.2591510
Abstract
Bladder cancer is a prevalent and lethal malignancy worldwide, with treatment options often limited by the development of chemoresistance, especially to cisplatin-based regimens. In this study, we identified ubiquitin-specific protease 54 (USP54) as…
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