Pharmaceutical development and technologyAnimalsXanthonesRatsSprague-DawleySolubility
Preparation, characterization and in vivo studies of amorphous solid dispersion of gambogic acid with meglumine.
Zhongcheng Ke, Xiaoling Cheng, Yimin Niu, Xuwen Chai, Wenwen Fang, Ping Wang, Yan Gong, Zitong Zhu, Yibin Feng
Published: 202510.1080/10837450.2025.2591742
Abstract
The aim of this study was to develop an amorphous solid dispersion system utilizing meglumine (MG) as an alkalizing matrix to improve the dissolution rate and oral bioavailability of gambogic acid (GA). Solid dispersion of GA with MG (GA/MG-SD) was f…
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