Role of selective U-II receptor antagonists in modifying vascular function in intact and denuded aortic diabetic rats.

BACKGROUND: Urotensin-II (U-II) is a potent vasoconstrictor acting via UT receptors. Endothelial buffering normally restrains U-II signaling, but this protection is diminished in diabetes mellitus, contributing to vascular dysfunction. Selective UT a…

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