Free radical research
Spermidine diminishes lipopolysaccharide-induced myocardial ferroptosis through the Keap1-Nrf2/HO-1 pathway.
Jun He, Xiaohong Zhang, Hongxin Jiang, Zhaoyu Liu, Yuwen Dai, Pin Zhao, Jianke Kuai
Published: 202610.1080/10715762.2026.2620031
Abstract
Spermidine (SPD) is a naturally-occurring polyamine with a range of unique properties including anti-inflammatory, antioxidant, and cardioprotective effects. Ferroptosis, a form of cell death that is regulated by reactive oxygen species (ROS), plays…
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