Free radical researchAnimalsFerroptosisMelatoninHepatolenticular DegenerationRats
Melatonin inhibits liver ferroptosis in copper-laden rats: a potential therapy mechanism underlying Wilson's disease.
Lihong Zhou, Xiaodan Zhang, Yulong Peng, Shiyu He, Zhen Mao, Jin Cai, Hong Yang, Peili Huang
Published: 202510.1080/10715762.2025.2593446
Abstract
Wilson's disease (WD) is an autosomal recessive disorder associated with impaired copper metabolism that results in hepatic manifestations. However, as a rare disease, the underlying pathogenic mechanism and drug development have lagged behind. Studi…
Preview only. Read the full abstract at the source