Journal of drug targeting
Use of methotrexate carried in lipid core nanoparticles in rats with endotoxemia: a possible new strategy for the treatment of the cardiac dysfunction in sepsis.
Natalia de Menezes Lopes, Maria Carolina Guido, Priscila de Oliveira Carvalho, Camila Inagaki Albuquerque, Leonardo Jensen, Victor Debbas, Ludhmila Abrahão Hajjar, Raul Cavalcante Maranhão
Published: 202510.1080/1061186X.2025.2585040
Abstract
Cardiac dysfunction is a major cause of death in endotoxemia. Previously, we showed that methotrexate (MTX) carried in lipid-core nanoparticles (LDE) can modulate immune response and increase myocardial angiogenesis. The aim was to test the effects o…
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