Critical reviews in microbiology
Host-inspired anti-virulence strategies against membrane-targeting bacterial toxins: modification and mimicry.
O'Rorke K Smith, Lyn M Wise, Jeremy Simcock, Dhammika Leshan Wannigama, Eduard B Babiychuk, Daniel Pletzer
Published: 202510.1080/1040841X.2025.2605546
Abstract
Pore-forming toxins (PFTs) are essential virulence factors produced by many bacterial pathogens, enabling tissue invasion, nutrient acquisition, and immune evasion. Neutralizing these toxins offers a promising therapeutic avenue to mitigate infection…
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