Critical reviews in food science and nutrition
Single-cell omics for nutrition research: an emerging opportunity for human-centric investigations.
Manuela Cassotta, Yasmany Armas Diaz, Danila Cianciosi, Bei Yang, Zexiu Qi, Ge Chen, Santos Gracia Villar, Luis Alonso Dzul Lopez, Giuseppe Grosso, José L Quiles, Jianbo Xiao, Maurizio Battino, Francesca Giampieri
Published: 202510.1080/10408398.2025.2566387
Abstract
Understanding how dietary compounds affect human health is challenged by their molecular complexity and cell-type-specific effects. Conventional multi-cell type (bulk) analyses obscure cellular heterogeneity, while animal and standard in vitro models…
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