International journal of radiation biologyHumansFerroptosisGlioblastomaPhospholipid Hydroperoxide Glutathione PeroxidaseTemozolomide
POT1-AS1/IGF2BP2/GPX4 promotes temozolomide resistance and radioresistance in glioblastoma by inhibiting ferroptosis.
Qiufeng Dong, Junli Huo, Zhifeng Yan, Juan Li, Xiaoyan Chen, Liwen Li, Haining Zhen
Published: 202610.1080/09553002.2025.2588395
Abstract
AIM: Glioblastoma (GBM) is an aggressive brain tumor characterized by resistance to temozolomide (TMZ) and radiotherapy. This study investigates the role of long non-coding RNA POT1-AS1 in modulating TMZ resistance (TMZR) and radiation-resistant (RR)…
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