Ocular immunology and inflammationHumansRetinal Pigment EpitheliumSTAT3 Transcription FactorMacular EdemaSignal Transduction
Gain-of-Function Variant in STAT3 and Retinal Macular Edema: Insights into the IL-6 R/JAK/STAT3 Pathway in Retinal Pigment Epithelium.
Zijun Zhou, Mirthe S Lourens, Kornvalee Meesilpavikkai, Tom Missotten, Mirjam van Velthoven, Kasiphak Kaikaew, Suphattra Phakham, Peter J van der Spek, Sigrid M A Swagemakers, Narissara Suratannon, Nattiya Hirankarn, Hanna IJspeert, Willem A Dik, P Martin van Hagen
Published: 202610.1080/09273948.2025.2551803
Abstract
PURPOSE: The IL-6 R/JAK/STAT3 signaling pathway is implicated in non-infectious uveitis-associated macular edema, and its inhibition using monoclonal anti-IL-6 receptor therapy has been associated with clinical improvement. However, the underlying pa…
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