Immunological investigations
Autophagy Sustained the Activation and Survival of Liver-infiltrating CD8+ T Cells in Primary Biliary Cholangitis.
Jie Li, Miao He, Jianguo Zhang, Binghui Liu, Qingqing Xia, Bihong Zhu, Tianzhen Lin, Zaixing Yang
Published: 202510.1080/08820139.2025.2576138
Abstract
BACKGROUND: Primary biliary cholangitis (PBC) fundamentally manifests as an immune-mediated disorder where T cell-driven autoreactivity persists as the principal pathogenic mechanism. Despite this understanding, immunosuppressive therapies have faile…
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