Immunological investigations
NLRP12 Mediates Macrophage Polarization and Drives Host Defense Against Severe Klebsiella Pneumoniae Pneumonia.
Shunjin Zhao, Xiaoyi Tong, Qi Long, Yaling Huang, Lini Zheng, Xinhao Mao, Xin Yu
Published: 202510.1080/08820139.2025.2551219
Abstract
BACKGROUND: Klebsiella pneumoniae (Kp) is a bacterial pathogen that results in diverse infections. NLRP12, one of the NLR family members, acts as an inflammasome in response to specific infections. Herein, the role and mechanisms of NLRP12 involving…
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