Systematic study of the structure and aggregation propensity of transthyretin under different pH conditions.

Transthyretin (TTR) is a homo-tetrameric transport protein that carries thyroxine (T4) and retinol-binding protein (RBP). Dissociation of native tetramer of TTR (due to mutations or age-related oxidative modifications) into misfolded monomeric subuni…

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