Structural and energetic insights into cGAS-DNA monomer and oligomer formation: an MD and mM/GBSA study.

Upon binding to cytosolic DNA, the cyclic GMP-AMP synthase (cGAS) is activated to catalyze the synthesis of cGAMP, which then activates downstream effectors and induces innate immune responses. The activation of cGAS relies on the formation of cGAS-D…

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