Journal of biomolecular structure & dynamics
pH modulates amyloid-β42 conformation in lipid membranes: evidence from circular dichroism, Raman spectroscopy, and molecular dynamics simulations.
Khlood A A Abdeljawaad, Yersultan Arynbek, Kahramon Mamatkulov, Huy Duc Le, Mahmoud A A Ibrahim, Gamal A H Mekhemer, Grigory Arzumanyan
Published: 202510.1080/07391102.2025.2572296
Abstract
Alzheimer's disease (AD) progression is strongly linked to conformational changes of amyloid-β42 (Aβ42) in neuronal membranes. This study examined the influence of pH on Aβ42 conformation in 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) membrane…
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