Drug metabolism reviews
Relevance of Reactive Metabolites and Covalent Binding to Drug Candidate Selection.
Jack Uetrecht
Published: 202610.1080/03602532.2026.2620682
Abstract
Idiosyncratic drug reactions (IDRs)represent a major risk for drug development. Current methods do not reliably predict IDR risk. There is strong evidence that most IDRs are immune-mediated. An adaptive immune response requires 2 signals: signal 1 re…
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