Experimental lung researchCalpainForkhead Box Protein O3AnimalsPhosphorylationHumans
Nuclear accumulated µ-calpain enhances FoxO3a phosphorylation in AT2 cell and exacerbates pulmonary fibrosis.
Qiao Li, Yu Tian, Yu-Tong Ye, Yi-Liang Zhu, Ling-Hui Pan, Shi-Yi Xu, Miao-Feng Wang, Yuan Fang, Lu-Yao Han, Jian-Ming Wu, Jing-Jun Zhou, Feng Zhao
Published: 202510.1080/01902148.2025.2583666
Abstract
BACKGROUND: µ-calpain is implicated in idiopathic pulmonary fibrosis (IPF), however its role in the aberrant alveolar epithelial type II (AT2) cells differentiation, and its relationship with FoxO3a, an important transcription factor involving in tis…
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