Neurological research
Astrocyte S1P1 regulates mitochondrial autophagy in inflammation and neuronal injury after epilepsy.
Lixiang Yang, Chao Cheng, Weifeng Miao, Zhaodi Liao, Weiyi Huang, Qijian Zhang, Yuanrun Zhu, Jun Sun, Junfei Shao
Published: 202510.1080/01616412.2025.2602687
Abstract
OBJECTIVE: The aim of this study is to explore the mechanism by which sphingosine 1-phosphate receptor 1 (S1P1) regulates mitochondrial autophagy through PHB2, thereby exacerbating inflammation and nerve damage after epilepsy. METHODS: This study inv…
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