Neurological research
FGF21 attenuates traumatic brain injury-induced ferroptosis via activation of the Nrf2/GPX4 pathway.
Yunfeng Xu, Andong Zhang, Guangning Zhang, Jiadong Qian
Published: 202510.1080/01616412.2025.2597834
Abstract
BACKGROUND: Traumatic brain injury (TBI) triggers secondary neuronal damage via oxidative stress and ferroptosis. This study examines the neuroprotective effect of fibroblast growth factor 21 (FGF21) in TBI and its regulation of the Nrf2/GPX4 signali…
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