Neurological research
SIRT1 activates autophagy through Smad3 deacetylation and inhibits microglia activation to relieve SCI.
Hongbo Chen, Rongmei Li, Ya Li, Baocai Hong, Xiongli Fu, Pinwen Tu, Chaochao Yang, Yongqian Deng, Yang Zhang, Shaokun Lv
Published: 202510.1080/01616412.2025.2571945
Abstract
BACKGROUND: In the state of spinal cord injury (SCI), microglia over-activate and release inflammatory factors, which aggravate SCI. The neuroprotective factor known as sirtuin 1 (SIRT1) is intricately linked to the activation of BV2. This research e…
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