Drug and chemical toxicology
N-acetyl cysteine and vitamin E attenuate acrylamide-induced hepatotoxicity via regulation of miRNA-34a and P53/Nrf2/SIRT 1 signaling pathways.
Fatma A Gad, Mahmoud Abdelghaffar Emam, Abeer A Abdelhameed, Doaa M Khalil, Eman A Elgebaly, Maha M Bakhuraysah, Shatha B Albattal, Khalid S Alotaibi, Mohamed Mohamed Soliman
Published: 202510.1080/01480545.2025.2574393
Abstract
The present study is aimed to evaluate the hepatoprotective role of N-acetyl cysteine (NAC) and vitamin E (VE), as potent antioxidants, against acrylamide (ACR)-induced hepatotoxicity via investigation of alterations in miRNA-34a, P53, Nrf2, and SIRT…
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