Xenobiotica; the fate of foreign compounds in biological systemsParoxetineAnimalsHumansRatsAntidepressive Agents
Studies addressing potential bioactivation and genotoxicity liabilities of the N-nitroso derivative of the antidepressant paroxetine.
Carley J S Heck, Heather Eng, Jennifer R Cheung, Joseph Tillotson, Krista L Dobo, Amit S Kalgutkar
Published: 202510.1080/00498254.2025.2586614
Abstract
The mutagenicity and bioactivation potential of N-nitrosoparoxetine, a N-nitrosamine drug substance related impurity (NDSRI) of the marketed antidepressant paroxetine, was characterised in vitro.N-Nitrosoparoxetine was not mutagenic in an OECD 471-co…
Preview only. Read the full abstract at the source