Proceedings of the National Academy of Sciences of the United States of AmericaHumansProtein BindingBinding SitesDrug DesignMembrane Proteins
Mapping targetable sites on the human surfaceome for the design of novel binders.
Petra E M Balbi, Ahmed Sadek, Anthony Marchand, Ta-Yi Yu, Jovan Damjanovic, Sandrine Georgeon, Joseph Schmidt, Simone Fulle, Che Yang, Hamed Khakzad, Bruno E Correia
Published: 202610.1073/pnas.2506269123
Abstract
The human cell surfaceome, integral to cell communication and disease mechanisms, presents a prime target for therapeutic intervention. De novo protein binder design against these cell surface proteins offers a promising yet underexplored strategy fo…
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