Proceedings of the National Academy of Sciences of the United States of AmericaAnimalsReceptorsMetabotropic GlutamateMiceCerebellum
mGluR1 signaling is necessary for strengthening winner climbing fiber inputs in the developing mouse cerebellum.
Miwako Yamasaki, Taisuke Miyazaki, Kouichi Hashimoto, Norio Takei, Atsu Aiba, Masanobu Kano, Masahiko Watanabe
Published: 202610.1073/pnas.2425460123
Abstract
Functional neural circuits are sculpted by strengthening frequently used synapses and removing unnecessary connections. At birth, cerebellar Purkinje cells receive inputs with similar synaptic strengths from multiple climbing fibers (CFs). During pos…
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